The smart Trick of ceesdekker That Nobody is Discussing
The smart Trick of ceesdekker That Nobody is Discussing
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Working with solitary-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests involve:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
Within the similar time, the team of Paul McEuen, who was then based mostly on the University of California, Berkeley, confirmed related outcomes on ropes of bundled nanotubes. According to the wrapping angle, nanotubes can are available in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified working with scanning tunnelling spectroscopy experiments.
Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
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Our investigate ranges within the biophysics of DNA to artificial cells and further than. Be sure to take a look underneath for the spectrum of our latest initiatives.
All parameters have been the exact same for every panel in this movie, aside from the Original placement of the 6hb rod (shown in blue) within the nanopore. Simulations that terminated early on account of translocation with the rod in the pore are marked by a gray background.
2011, 1st in vitro measurements of transport across just one biomimetic nuclear pore complicated; advancement of ceesdekker multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination
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Really neat, but that wasn’t truly wherever my interest lay. I wished to pioneer And that i experienced the feeling that was no more probable, because the most exciting essential insights had currently been uncovered. But my subject experienced developed several enjoyable new tools to measure specific molecules. I made a decision that I wished to implement this to biology, to have a look at it from the Actual physical point of view.’
In 1993 he was appointed as Affiliate Professor at Delft University of Engineering. During the mid-1990s Dekker and his crew obtained good results with the invention of your electronic Attributes of carbon nanotubes, the very first solitary-molecule transistor together with other nanoscience.
1999, very first measurement of the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for your new Luttinger description of interacting electrons in nanotubes
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-array conformational modifications in Mre11/DNA repair service complexes; and very first pressure measurements on a DNA molecule in the nanopore
‘I am driven by speculate and questions. On a material degree I uncover responses in physics, but I experience my deepest happiness with God. That faith also drives my science And the way I take care of persons.