A Secret Weapon For ceesdekker
A Secret Weapon For ceesdekker
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Utilizing single-molecule optical and AFM imaging and drive-spectroscopy tactics, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests include:
Our team studies bacterial mobile division and it is aiming to represent a ‘base up biology’ in synthetic cells that will autonomously divide. Our main interest lies in mobile division, chromatin framework, and spatial Management.
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However, For many years following Iijima’s report, the manufacture of clean nanotubes was cumbersome. In 1996, on the other hand, the group of Richard Smalley at Rice University managed to supply one-walled carbon nanotubes at higher generate. Soon right after, I contacted Smalley, and we made a decision to be a part of forces to evaluate the transportation through a solitary carbon nanotube.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review in the dynamics DNA supercoils and the invention of supercoil hopping
Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quickly electron relay to redox enzymes and zeptomole protein-movie voltammetry
What distinguishes biology from chemistry is usually that these elements together make up a residing system. The key of said daily life, I believe, lies during the interactions, the interplay of All those molecules. The big problem regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from simple molecules in the extremely sophisticated units we see today? We don't know. I need to operate on these kinds of massive, open up queries.’
Nanopores signify an elegant and https://www.ceesdekker.net flexible Software to measure single molecules. We study novel detection modes with sound-state nanopores in addition to different approaches to measure proteins with nanopores. Tasks encompass the following:
‘You should not just consider the queries of tomorrow, but in addition take into account the queries on the day right after tomorrow’
one). The current–voltage curves confirmed substantial modulations with gate voltage, even at place temperature, which was in step with band bending inside of a ~0.6 eV bandgap semiconducting nanotube. These details also showed the conductance might be modulated by 6 orders of magnitude by changing the gate voltage. The final results of this operate — a room-temperature transistor constructed from just one carbon nanotube molecule — were being printed in Character in May 1998.
[fourteen] In 2005 Dekker became involved with Netherlands-wide discussions about Clever Style, a motion that he has because Plainly distanced himself from. Dekker advocates that science and religion will not be in opposition but may be harmonized.
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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim in the pore is highlighted in pink, plus a 3D rendering of the motion of the DNA rod is shown.